Timeline

  1. Plescia, J.; Moitessier, N. Design and discovery of boronic acid drugs. European Journal of Medicinal Chemistry 2020, 112270. link

  2. Plescia, J.; Dufresne, C.; Janmamode, N.; Wahba, A. S.; Mittermaier, A. K.; Moitessier, N. Discovery of covalent prolyl oligopeptidase boronic ester inhibitors. European Journal of Medicinal Chemistry 2020, 185, 111783. link

  3. Plescia, J.; De Cesco, S.; Burai Patrascu, M.; Kurian, J.; Di Trani, J.; Dufresne, C.; Wahba, A. S.; Janmamode, N.; Mittermaier, A. K.; Moitessier, N. Integrated Synthetic, Biophysical, and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein Alpha. Journal of Medicinal Chemistry 2019, 62, 7874-7884. link

  4. Mariaule G., De Cesco S., Airaghi F., Kurian J., Schiavini P., Rocheleau S., Huskić I., Auclair K., Mittermaier A., Moitessier N. 3-Oxo-hexahydro-1H-isoindole-4-carboxylic acid as a Drug Chiral Bicyclic Scaffold: Structure-based Design and Preparation of Conformationally Constrained Covalent and Non-Covalent Prolyl Oligopeptidase Inhibitors. Journal of Medicinal Chemistry 2016, 59, 4221–4234. link

  5. Schiavini P., Pottel J., Moitessier N., Auclair K. Metabolic Instability of Cyanothiazolidine-Based Prolyl Oligopeptidase Inhibitors: a Structural Assignment Challenge and Potential Medicinal Chemistry Implications. ChemMedChem 2015, 10, 1174-1183. link

  6. De Cesco S., Deslandes S., Therrien E., Levan D., Cueto M., Schmidt R., Cantin L.-D., Mittermaier A., Juillerat-Jeanneret L., Moitessier N. Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells. Journal of Medicinal Chemistry 2012, 55, 6306-6315. link

  7. Lawandi J., Gerber-Lemaire S., Juillerat-Jeanneret L., Moitessier N. Inhibitors of prolyl oligopeptidases for the therapy of human diseases: Defining diseases and inhibitors. Journal of Medicinal Chemistry 2010, 53, 3423-3438. link

  8. Lawandi J., Toumieux S., Seyer V., Campbell P., Thielges S., Juillerat-Jeanneret L., Moitessier N., Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors Journal of Medicinal Chemistry 2009, 52, 6672-6684. link

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